I73T (p.Ile73Thr) variant of MCM2 (P49736)
I73T (p.Ile73Thr) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
I73T (p.Ile73Thr) variant details
- p.Ile73Thr
- gnomAD rs1331240380
- Missense
- Variant Prioritization Score for Impact Estimate 0.395
- REVEL 0.28
- MetaLR 0.10
- MetaSVM -1.00
- CADD 26.70
- PolyPhen-2 0.49
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available