G61E (p.Gly61Glu) variant of MCM2 (P49736)
G61E (p.Gly61Glu) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
G61E (p.Gly61Glu) variant details
- p.Gly61Glu
- ExAC rs778367347
- TOPMed rs778367347
- gnomAD rs778367347
- Missense
- Variant Prioritization Score for Impact Estimate 0.282
- REVEL 0.07
- MetaLR 0.02
- MetaSVM -1.08
- CADD 21.40
- PolyPhen-2 0.00
- SIFT 0.75
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available