D36N (p.Asp36Asn) variant of MCM2 (P49736)
D36N (p.Asp36Asn) in MCM2 (P49736) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
D36N (p.Asp36Asn) variant details
- p.Asp36Asn
- NCI-TCGA Cosmic COSV5403
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.356
- REVEL 0.13
- MetaLR 0.08
- MetaSVM -1.07
- CADD 24.80
- PolyPhen-2 0.01
- SIFT 0.11
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available