A37S (p.Ala37Ser) variant of MCM2 (P49736)
A37S (p.Ala37Ser) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data, published literature, and structural context.
A37S (p.Ala37Ser) variant details
- p.Ala37Ser
- gnomAD 3-127599420-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.312
- REVEL 0.17
- MetaLR 0.06
- MetaSVM -1.07
- CADD 22.10
- PolyPhen-2 0.00
- SIFT 0.19
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available