A15V (p.Ala15Val) variant of MCM2 (P49736)
A15V (p.Ala15Val) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
A15V (p.Ala15Val) variant details
- p.Ala15Val
- TOPMed rs2074287843
- Missense
- Variant Prioritization Score for Impact Estimate 0.164
- REVEL 0.05
- MetaLR 0.09
- MetaSVM -1.00
- CADD 13.30
- PolyPhen-2 0.00
- SIFT 0.23
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available