P66L (p.Pro66Leu) variant of MCL1 (Q07820)
P66L (p.Pro66Leu) in MCL1 (Q07820) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
P66L (p.Pro66Leu) variant details
- p.Pro66Leu
- ExAC rs747459222
- TOPMed rs747459222
- gnomAD rs747459222
- Missense
- Variant Prioritization Score for Impact Estimate 0.185
- REVEL 0.03
- CADD 21.90
- PolyPhen-2 0.01
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 3.8e-05)
- Structural context available