P65L (p.Pro65Leu) variant of MCL1 (Q07820)
P65L (p.Pro65Leu) in MCL1 (Q07820) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
P65L (p.Pro65Leu) variant details
- p.Pro65Leu
- cosmic curated COSV57190
- TOPMed rs1473394310
- gnomAD rs1473394310
- Missense
- Variant Prioritization Score for Impact Estimate 0.273
- REVEL 0.09
- CADD 22.00
- PolyPhen-2 0.01
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available