L4F (p.Leu4Phe) variant of MCL1 (Q07820)
L4F (p.Leu4Phe) in MCL1 (Q07820) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
L4F (p.Leu4Phe) variant details
- p.Leu4Phe
- cosmic curated COSV57190
- gnomAD rs1647992246
- Missense
- Variant Prioritization Score for Impact Estimate 0.0826
- REVEL 0.02
- CADD 13.10
- PolyPhen-2 0.00
- SIFT 0.17
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available