L21V (p.Leu21Val) variant of MCL1 (Q07820)
L21V (p.Leu21Val) in MCL1 (Q07820) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.05 / 1. The record also includes population frequency data and structural context.
L21V (p.Leu21Val) variant details
- p.Leu21Val
- ExAC rs755515463
- gnomAD rs755515463
- Missense
- Variant Prioritization Score for Impact Estimate 0.0548
- REVEL 0.02
- CADD 6.03
- PolyPhen-2 0.10
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 3.3e-05)
- Structural context available