L12F (p.Leu12Phe) variant of MCL1 (Q07820)
L12F (p.Leu12Phe) in MCL1 (Q07820) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
L12F (p.Leu12Phe) variant details
- p.Leu12Phe
- gnomAD rs1229708032
- Missense
- Variant Prioritization Score for Impact Estimate 0.317
- REVEL 0.12
- CADD 23.90
- PolyPhen-2 0.78
- SIFT 0.16
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available