I57T (p.Ile57Thr) variant of MCL1 (Q07820)
I57T (p.Ile57Thr) in MCL1 (Q07820) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
I57T (p.Ile57Thr) variant details
- p.Ile57Thr
- 1000Genomes rs587657093
- ExAC rs587657093
- TOPMed rs587657093
- gnomAD rs587657093
- Missense
- Variant Prioritization Score for Impact Estimate 0.186
- REVEL 0.06
- CADD 7.65
- PolyPhen-2 0.14
- SIFT 0.61
- Most common in the 1KG:JPT population (allele frequency 0.0049)
- Structural context available