G51E (p.Gly51Glu) variant of MCL1 (Q07820)
G51E (p.Gly51Glu) in MCL1 (Q07820) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
G51E (p.Gly51Glu) variant details
- p.Gly51Glu
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.315
- REVEL 0.10
- CADD 22.30
- PolyPhen-2 0.42
- SIFT 0.23
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.3e-05)
- Structural context available