G32A (p.Gly32Ala) variant of MCL1 (Q07820)
G32A (p.Gly32Ala) in MCL1 (Q07820) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
G32A (p.Gly32Ala) variant details
- p.Gly32Ala
- ExAC rs770152297
- TOPMed rs770152297
- gnomAD rs770152297
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.161
- REVEL 0.03
- CADD 9.05
- PolyPhen-2 0.00
- SIFT 0.44
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 9.1e-06)
- Structural context available