G18W (p.Gly18Trp) variant of MCL1 (Q07820)
G18W (p.Gly18Trp) in MCL1 (Q07820) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
G18W (p.Gly18Trp) variant details
- p.Gly18Trp
- ExAC rs753196937
- gnomAD rs753196937
- Missense
- Variant Prioritization Score for Impact Estimate 0.414
- REVEL 0.24
- CADD 26.10
- PolyPhen-2 0.95
- SIFT 0.00
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available