W16L (p.Trp16Leu) variant of MC4R (Melanocortin receptor 4)
W16L (p.Trp16Leu) in MC4R (Melanocortin receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, published literature, and structural context.
W16L (p.Trp16Leu) variant details
- p.Trp16Leu
- gnomAD 18-60372303-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.357
- REVEL 0.14
- MetaLR 0.06
- MetaSVM -1.08
- CADD 20.30
- PolyPhen-2 0.00
- SIFT 0.84
- Population evidence available
- Structural context available
- Literature evidence available