V67G (p.Val67Gly) variant of MC4R (Melanocortin receptor 4)
V67G (p.Val67Gly) in MC4R (Melanocortin receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data, published literature, and structural context.
V67G (p.Val67Gly) variant details
- p.Val67Gly
- gnomAD 18-60372150-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.309
- REVEL 0.26
- MetaLR 0.01
- MetaSVM -0.86
- CADD 20.90
- PolyPhen-2 0.00
- SIFT 0.37
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available