V65M (p.Val65Met) variant of MC4R (Melanocortin receptor 4)
V65M (p.Val65Met) in MC4R (Melanocortin receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.86 / 1. The record also includes population frequency data and structural context.
V65M (p.Val65Met) variant details
- p.Val65Met
- TOPMed rs1598932401
- Missense
- Variant Prioritization Score for Impact Estimate 0.863
- REVEL 0.91
- MetaLR 0.87
- MetaSVM 1.00
- CADD 25.70
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available