R165G (p.Arg165Gly) variant of MC4R (Melanocortin receptor 4)

R165G (p.Arg165Gly) in MC4R (Melanocortin receptor 4) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as pathogenic/likely pathogenic in the context of BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20; Early onset severe obesity; Obesity. The record also includes structural context.

R165G (p.Arg165Gly) variant details