L15F (p.Leu15Phe) variant of MC4R (Melanocortin receptor 4)
L15F (p.Leu15Phe) in MC4R (Melanocortin receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
L15F (p.Leu15Phe) variant details
- p.Leu15Phe
- Ensembl rs765520842
- Missense
- Variant Prioritization Score for Impact Estimate 0.108
- REVEL 0.02
- MetaLR 0.02
- MetaSVM -1.01
- CADD 13.70
- PolyPhen-2 0.00
- SIFT 0.55
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available