I63F (p.Ile63Phe) variant of MC4R (Melanocortin receptor 4)
I63F (p.Ile63Phe) in MC4R (Melanocortin receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
I63F (p.Ile63Phe) variant details
- p.Ile63Phe
- ExAC rs750396034
- gnomAD rs750396034
- Missense
- Variant Prioritization Score for Impact Estimate 0.29
- REVEL 0.28
- MetaLR 0.04
- MetaSVM -1.18
- CADD 24.70
- PolyPhen-2 0.95
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 6e-05)
- Structural context available