G32R (p.Gly32Arg) variant of MC4R (Melanocortin receptor 4)
G32R (p.Gly32Arg) in MC4R (Melanocortin receptor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, published literature, and structural context.
G32R (p.Gly32Arg) variant details
- p.Gly32Arg
- gnomAD 18-60372256-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.284
- REVEL 0.13
- MetaLR 0.09
- MetaSVM -1.09
- CADD 18.20
- PolyPhen-2 0.00
- SIFT 0.08
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available