T69I (p.Thr69Ile) variant of MAPT (P10636)
T69I (p.Thr69Ile) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
T69I (p.Thr69Ile) variant details
- p.Thr69Ile
- gnomAD rs1168788082
- Missense
- Variant Prioritization Score for Impact Estimate 0.329
- REVEL 0.14
- MetaLR 0.18
- MetaSVM -0.93
- CADD 26.40
- PolyPhen-2 1.00
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 1.6e-05)
- Structural context available