T17S (p.Thr17Ser) variant of MAPT (P10636)
T17S (p.Thr17Ser) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data and structural context.
T17S (p.Thr17Ser) variant details
- p.Thr17Ser
- ExAC rs765496574
- gnomAD rs765496574
- Missense
- Variant Prioritization Score for Impact Estimate 0.0739
- REVEL 0.03
- MetaLR 0.05
- MetaSVM -1.06
- CADD 0.01
- PolyPhen-2 0.67
- SIFT 0.74
- Most common in the Non-Finnish European population (allele frequency 3.4e-06)
- Structural context available