S68T (p.Ser68Thr) variant of MAPT (P10636)
S68T (p.Ser68Thr) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
S68T (p.Ser68Thr) variant details
- p.Ser68Thr
- TOPMed rs1447868249
- gnomAD rs1447868249
- Missense
- Variant Prioritization Score for Impact Estimate 0.371
- REVEL 0.20
- MetaLR 0.19
- MetaSVM -0.89
- CADD 25.50
- PolyPhen-2 0.06
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 5e-05)
- Structural context available