P59S (p.Pro59Ser) variant of MAPT (P10636)
P59S (p.Pro59Ser) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, published literature, and structural context.
P59S (p.Pro59Ser) variant details
- p.Pro59Ser
- gnomAD 17-45971900-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.191
- REVEL 0.04
- MetaLR 0.09
- MetaSVM -1.03
- CADD 22.80
- PolyPhen-2 0.97
- SIFT 0.03
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.8e-05)
- Structural context available
- Literature evidence available