K67R (p.Lys67Arg) variant of MAPT (P10636)
K67R (p.Lys67Arg) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
K67R (p.Lys67Arg) variant details
- p.Lys67Arg
- ExAC rs754588669
- TOPMed rs754588669
- Missense
- Variant Prioritization Score for Impact Estimate 0.245
- REVEL 0.09
- MetaLR 0.06
- MetaSVM -1.02
- CADD 26.00
- PolyPhen-2 0.52
- SIFT 0.05
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.8e-05)
- Structural context available