H32Y (p.His32Tyr) variant of MAPT (P10636)
H32Y (p.His32Tyr) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, published literature, and structural context.
H32Y (p.His32Tyr) variant details
- p.His32Tyr
- gnomAD 17-45962431-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.254
- REVEL 0.06
- MetaLR 0.05
- MetaSVM -1.10
- CADD 20.50
- PolyPhen-2 0.89
- SIFT 0.90
- Population evidence available
- Structural context available
- Literature evidence available