G37S (p.Gly37Ser) variant of MAPT (P10636)
G37S (p.Gly37Ser) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
G37S (p.Gly37Ser) variant details
- p.Gly37Ser
- ESP rs146476223
- TOPMed rs146476223
- gnomAD rs146476223
- Missense
- Variant Prioritization Score for Impact Estimate 0.36
- REVEL 0.10
- MetaLR 0.18
- MetaSVM -0.81
- CADD 25.10
- PolyPhen-2 0.99
- SIFT 0.40
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available