G37C (p.Gly37Cys) variant of MAPT (P10636)
G37C (p.Gly37Cys) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, published literature, and structural context.
G37C (p.Gly37Cys) variant details
- p.Gly37Cys
- gnomAD 17-45962446-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.362
- REVEL 0.09
- MetaLR 0.22
- MetaSVM -0.66
- CADD 26.20
- PolyPhen-2 1.00
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available