G27W (p.Gly27Trp) variant of MAPT (P10636)
G27W (p.Gly27Trp) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data, published literature, and structural context.
G27W (p.Gly27Trp) variant details
- p.Gly27Trp
- gnomAD 17-45962416-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.266
- REVEL 0.12
- MetaLR 0.15
- MetaSVM -1.04
- CADD 23.40
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 7.7e-05)
- Structural context available
- Literature evidence available