G19W (p.Gly19Trp) variant of MAPT (P10636)
G19W (p.Gly19Trp) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
G19W (p.Gly19Trp) variant details
- p.Gly19Trp
- gnomAD 17-45962392-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.21
- REVEL 0.10
- MetaLR 0.10
- MetaSVM -1.06
- CADD 22.40
- PolyPhen-2 1.00
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 5.8e-05)
- Structural context available
- Literature evidence available