D25Y (p.Asp25Tyr) variant of MAPT (P10636)
D25Y (p.Asp25Tyr) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, published literature, and structural context.
D25Y (p.Asp25Tyr) variant details
- p.Asp25Tyr
- gnomAD 17-45962410-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.287
- REVEL 0.14
- MetaLR 0.09
- MetaSVM -1.04
- CADD 23.50
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available