D25N (p.Asp25Asn) variant of MAPT (P10636)
D25N (p.Asp25Asn) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, published literature, and structural context.
D25N (p.Asp25Asn) variant details
- p.Asp25Asn
- gnomAD 17-45962410-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.224
- REVEL 0.04
- MetaLR 0.09
- MetaSVM -1.06
- CADD 18.70
- PolyPhen-2 0.86
- SIFT 0.18
- Most common in the Non-Finnish European population (allele frequency 3.4e-06)
- Structural context available
- Literature evidence available