A15T (p.Ala15Thr) variant of MAPT (P10636)
A15T (p.Ala15Thr) in MAPT (P10636) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
A15T (p.Ala15Thr) variant details
- p.Ala15Thr
- cosmic curated COSV52240
- ESP rs143210139
- ExAC rs143210139
- gnomAD rs143210139
- Missense
- Variant Prioritization Score for Impact Estimate 0.156
- REVEL 0.09
- MetaLR 0.05
- MetaSVM -1.05
- CADD 9.83
- PolyPhen-2 0.05
- SIFT 0.39
- Most common in the Non-Finnish European population (allele frequency 5e-05)
- Structural context available