A15S (p.Ala15Ser) variant of MAPT (P10636)
A15S (p.Ala15Ser) in MAPT (P10636) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
A15S (p.Ala15Ser) variant details
- p.Ala15Ser
- rs143210139
- ESP rs143210139
- ExAC rs143210139
- gnomAD rs143210139
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.193
- REVEL 0.13
- MetaLR 0.09
- MetaSVM -1.03
- CADD 14.10
- PolyPhen-2 0.34
- SIFT 0.19
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available