V18L (p.Val18Leu) variant of MAPK1 (P28482)
V18L (p.Val18Leu) in MAPK1 (P28482) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V18L (p.Val18Leu) variant details
- p.Val18Leu
- ExAC rs768479151
- TOPMed rs768479151
- gnomAD rs768479151
- Missense
- Variant Prioritization Score for Impact Estimate 0.319
- REVEL 0.14
- CADD 19.10
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available
- MAPK1 VRT-11E: score 5.86