T94I (p.Thr94Ile) variant of MAPK1 (P28482)
T94I (p.Thr94Ile) in MAPK1 (P28482) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T94I (p.Thr94Ile) variant details
- p.Thr94Ile
- 1000Genomes rs141978504
- ESP rs141978504
- ExAC rs141978504
- TOPMed rs141978504
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.242
- REVEL 0.11
- CADD 23.10
- PolyPhen-2 0.26
- SIFT 0.04
- ClinVar: Uncertain significance (not provided)
- UniProt: Uncertain significance
- Most common in the 1KG:FIN population (allele frequency 0.0051)
- Structural context available
- MAPK1 DOX: score 7.52