R77H (p.Arg77His) variant of MAPK1 (P28482)
R77H (p.Arg77His) in MAPK1 (P28482) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R77H (p.Arg77His) variant details
- p.Arg77His
- Ensembl rs2145705620
- Missense
- Variant Prioritization Score for Impact Estimate 0.428
- REVEL 0.33
- CADD 21.70
- PolyPhen-2 0.05
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 5.4e-06)
- Structural context available
- MAPK1 VRT-11E: score 6.09