R77C (p.Arg77Cys) variant of MAPK1 (P28482)
R77C (p.Arg77Cys) in MAPK1 (P28482) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R77C (p.Arg77Cys) variant details
- p.Arg77Cys
- NCI-TCGA Cosmic COSV5318
- cosmic curated COSV53185
- gnomAD rs1330050442
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.6
- REVEL 0.61
- CADD 26.20
- PolyPhen-2 0.11
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- MAPK1 VRT-11E: score 6.09