N123S (p.Asn123Ser) variant of MAPK1 (P28482)
N123S (p.Asn123Ser) in MAPK1 (P28482) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data, experimental measurements, and structural context.
N123S (p.Asn123Ser) variant details
- p.Asn123Ser
- NCI-TCGA TCGA novel
- TOPMed rs2069136258
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.399
- REVEL 0.25
- CADD 23.70
- PolyPhen-2 0.31
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 6.3e-06)
- Structural context available
- MAPK1 DOX: score 7.68