L76V (p.Leu76Val) variant of MAPK1 (P28482)
L76V (p.Leu76Val) in MAPK1 (P28482) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L76V (p.Leu76Val) variant details
- p.Leu76Val
- ExAC rs761386086
- TOPMed rs761386086
- gnomAD rs761386086
- Missense
- Variant Prioritization Score for Impact Estimate 0.25
- REVEL 0.16
- CADD 22.70
- PolyPhen-2 0.08
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- MAPK1 DOX: score 7.03