L28H (p.Leu28His) variant of MAPK1 (P28482)
L28H (p.Leu28His) in MAPK1 (P28482) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L28H (p.Leu28His) variant details
- p.Leu28His
- cosmic curated COSV10586
- Missense
- Variant Prioritization Score for Impact Estimate 0.478
- REVEL 0.38
- CADD 27.70
- PolyPhen-2 0.82
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 1.1e-06)
- Structural context available
- MAPK1 DOX: score 7.79