G34C (p.Gly34Cys) variant of MAPK1 (P28482)
G34C (p.Gly34Cys) in MAPK1 (P28482) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.83 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G34C (p.Gly34Cys) variant details
- p.Gly34Cys
- NCI-TCGA Cosmic COSV5319
- cosmic curated COSV53190
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.825
- REVEL 0.95
- CADD 28.70
- PolyPhen-2 0.99
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.1e-06)
- Structural context available
- MAPK1 VRT-11E: score 6.08