G136E (p.Gly136Glu) variant of MAPK1 (P28482)
G136E (p.Gly136Glu) in MAPK1 (P28482) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G136E (p.Gly136Glu) variant details
- p.Gly136Glu
- rs1569090943
- NCI-TCGA Cosmic COSV5318
- cosmic curated COSV53187
- Ensembl rs1569090943
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.757
- REVEL 0.74
- CADD 26.50
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- MAPK1 DOX: score 6.98