C65S (p.Cys65Ser) variant of MAPK1 (P28482)
C65S (p.Cys65Ser) in MAPK1 (P28482) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, experimental measurements, and structural context.
C65S (p.Cys65Ser) variant details
- p.Cys65Ser
- ExAC rs756644901
- Missense
- Variant Prioritization Score for Impact Estimate 0.526
- REVEL 0.56
- CADD 23.30
- PolyPhen-2 0.32
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available
- MAPK1 SCH772984: score 7.24