A4T (p.Ala4Thr) variant of MAPK1 (P28482)
A4T (p.Ala4Thr) in MAPK1 (P28482) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A4T (p.Ala4Thr) variant details
- p.Ala4Thr
- TOPMed rs2070000610
- Missense
- Variant Prioritization Score for Impact Estimate 0.294
- REVEL 0.09
- CADD 21.80
- PolyPhen-2 0.00
- SIFT 0.34
- Most common in the African/African-American population (allele frequency 5.2e-05)
- Structural context available
- MAPK1 DOX: score 5.53