T25S (p.Thr25Ser) variant of MAP2K2 (P36507)
T25S (p.Thr25Ser) in MAP2K2 (P36507) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
T25S (p.Thr25Ser) variant details
- p.Thr25Ser
- gnomAD rs1161407396
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.311
- REVEL 0.11
- AlphaMissense 0.11
- MetaLR 0.18
- MetaSVM -0.86
- CADD 22.50
- PolyPhen-2 0.07
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Population evidence available
- Structural context available