T13I (p.Thr13Ile) variant of MAP2K2 (P36507)
T13I (p.Thr13Ile) in MAP2K2 (P36507) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
T13I (p.Thr13Ile) variant details
- p.Thr13Ile
- rs756416031
- ExAC rs756416031
- TOPMed rs756416031
- gnomAD rs756416031
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.326
- REVEL 0.14
- CADD 23.10
- PolyPhen-2 0.00
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available