S26I (p.Ser26Ile) variant of MAP2K2 (P36507)
S26I (p.Ser26Ile) in MAP2K2 (P36507) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
S26I (p.Ser26Ile) variant details
- p.Ser26Ile
- TOPMed rs1207931346
- gnomAD rs1207931346
- Missense
- Variant Prioritization Score for Impact Estimate 0.475
- REVEL 0.43
- CADD 22.80
- PolyPhen-2 0.00
- SIFT 0.27
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available