P22S (p.Pro22Ser) variant of MAP2K2 (P36507)
P22S (p.Pro22Ser) in MAP2K2 (P36507) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
P22S (p.Pro22Ser) variant details
- p.Pro22Ser
- ExAC rs766829845
- gnomAD rs766829845
- Missense
- Variant Prioritization Score for Impact Estimate 0.478
- REVEL 0.34
- CADD 20.80
- PolyPhen-2 0.00
- SIFT 0.60
- Most common in the Non-Finnish European population (allele frequency 8.2e-06)
- Structural context available